In this work, 2-bicyclo-[2.2.1]-hepten-2-oik acid and its alkali (sodium, potassium, lithium) and earth alkaline metals (calcium, barium, cesium) salts were synthesized. Naphtanic acids (2-bicyclo-[2.2.1]-hepten-2-oik. acid) are obtained applying Diels Alder method. The syntheses of carboxylates are optimally obtained by one step reaction. In all reactions, at pH around 7, the yields were close to each other. The structural characteristics and the physical and chemical properties of the acid and carboxylates are determined. Structural determination are done by IR and NMR methods. The antimicrobial activity of carboxylates was tested against six different Gram-positive bacteria by standard microdilution method. Gram-positive bacteria are the important cause for some human infections. In recent years they acquired antibiotic resistance against many antibiotics. Some alkali (Na, K, Li) and earth alkaline metals (Ca, Ba, Cs) are forming naphthenate compounds with naphthenic acids which may acts as a antimicrobial agents. The aim of this study was to synthesize the salts of carboxylic acids and test their antimicrobial activities against six different gram-positive bacteria. The MIC (minimal inhibition concentration) values for different salts of bicycle(2,2,1)-hept-5-en-2-carboxylic acid ranged between 1 to 32 mg/ml. Barium and calcium carboxylates were the most active agents against tested gram-positive organisms.
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