The ability to control the organization of compounds through supramolecular interactions offers a way of tuning the nano-scale structural features of a resulting polymeric aggregate. Subsequently, the ability to do this in a controlled and predictable manner offers the researcher a powerful tool in tailoring the properties of the resulting material. In this presentation we will discuss the use of ditopic small molecules, which have nucleobase derivatives at either chain end to control the nano-assembly of the monomer both in the solid state and on surfaces. The different self-assembly capability of the supramolecular motif, as well as the nature of the core of the monomer, results in the formation of different architectures which turn imparts different properties to the material.