Metal enolates generated via the deprotonation of ketonic substrates are key intermediates in organic synthesis. We have developed a series of novel Group 2 bisamides that display high reactivity in combination with excellent selectivity to mediate these deprotonation reactions. In addition, we are very interested in understanding the mechanism of action of these new bases. Structural studies in solution and in the solid state have provided critical first steps in this regard. Moreover, the magnesium-mediated reactions have proven to be amenable to detailed kinetic studies by UV-Vis spectroscopy and this has provided compelling evidence in elucidating their reaction mechanisms.