There is an increasing need for the design of high-performance polyfunctional (HPP) materials with side chains on the material for oriented and specific immobilization of biomolecules. The ideal material for such application should be hydrophilic, and must provide high-density anchor groups with low unspecific binding. This presentation will focus on the development of a new class of HPP materials for oriented immobilization of antibodies, nucleic acids and whole cells.