Luis Vargas, Queensborough Community College, Bayside, NY, Ralph Stephani, St. John's University, Jamaica, NY, and Renzo Samame, Queensborough Community College, Bayside, NY.
The synthesis of 1-hydroxy-1,-biphosphonic anilinum salt using TMSP is being reported. Chlorambucil is an alkylating agent of the nitrogen mustard group that works by binding DNA strands. The inclusion of a biphosphonate group, known for having exceptional affinity for bone tissue and as an inhibitor of bone resorption, increases the utility of this molecule as therapeutical agent against bone diseases.
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