Palladium is one of the transition metals most commonly used as catalyst in a variety of synthetic organic reactions leading to pharmaceutical compounds. However, a successful method must be found to remove the residual palladium from the reaction mixture, if the compounds are to be used in-vivo. Functionalized silica particles have been traditionally used as metal scavengers. More recently, our group has shown that a thiol-functionalized organoclay material, named Mg-MTMS, prepared by direct alkaline co-condensation of MgCl2.6H2O with (CH3O)3-Si-(CH2)3-SH exhibited a very high uptake affinity for aqueous heavy metal ions, Hg2+, Pb2+ and Cd2+. The high effectiveness of Mg-MTMS for the capture of these metals is attributed in part to the high concentration of complexing thiol groups (6.4 mmol SH per gram of Mg-MTMS). Knowing that the thiol functionality also has a high affinity for Pd, we tested the capacity of Mg-MTMS and a derivative solid, made from a 8:2 mole ratio mixture of mercaptopropyltrimethoxysilane ((CH3O)3-Si-(CH2)3-SH) and tetramethoxysilane ((CH3O)4-Si), to remove Pd2+ ions and complexes from aqueous and organic solutions. The stability of the solids in different solvents at various temperatures was investigated. The adsorption isotherms and the sorption kinetics of both materials were determined, and both adsorbents were compared for their effectiveness.