An open source science project, using blogs and wikis to make the scientific process as transparent as possible, has been the main focus of the research. Blogs are used to provide RSS information feeds on experimental details, molecules of interest to the projects, and the thinking process behind the design and evaluation of synthetic strategies. All experimental results, successful or not, are published on these sites and visitors are able to comment freely on the progress of the experiments as well as offer solutions to any obstacles that may arise. This allows us to get fresh ideas outside of the group from possibly more knowledgeable individuals. The main laboratory activity currently underway in our group centers on the synthesis of potential malaria inhibitors. Specifically, we are targeting inhibitors of enoyl reductase, an enzyme required by the malaria parasite to construct its cell wall. The nonprofit organization Find-A-Drug has provided us with a library of diketopiperazine targets predicted to inhibit enoyl reductase. Our strategy for their synthesis involves a Ugi reaction followed by a cyclization step. In this approach the versatility of the single step multi-component Ugi reaction can be exploited by combining an amino acid, amine, aldehyde and isonitrile. We have been getting feedback and suggestions to our reactions and ideas from scientists around the world. We hope to demonstrate that this approach of reporting experimental research in real time in an open forum will enable faster and more productive scientific progress.