Friday, 6 October 2006
South Ballroom (Binghamton Regency Hotel and Conference Center)

An HPLC Method for Determination of Trace Metals in Tissue Samples with Pre-Column Derivatization

Nancy E. Meagher and Christopher M. Witty. SUNY Cortland, Cortland, NY

An HPLC method for the determination of iron, zinc, and copper in tissue samples has been developed utilizing a photo-diode array detection system. The method relies upon acid digestion of the samples to free the metals from the sample matrix followed by pre-column derivatization with a common complexometric indicator. With extremely small amounts of sample available for some applications, a solid-phase extraction of the complexed metal ions can be included in the sample work-up to ensure measurable concentrations of the metal complexes are obtained for analysis.

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