To help students see the connection between their organic chemistry laboratory course and the “real world”, we have developed a synthesis of creatine monohydrate—a popular supplement used by athletes in sports requiring short bursts of energy. Using the same starting materials that are used in the commercial preparation of this supplement, undergraduate organic chemistry students are easily able to synthesize creatine. They purify the crude product by recrystallization and analyze it by thin layer chromatography, melting point, and low-field nuclear magnetic resonance spectroscopy. This synthesis illustrates the electrophilic nature of nitriles, as well as the nucleophilic nature of amines.