DNA biosensors are becoming increasingly used in mutation detection, hybridization reactions, genomic sequencing and identification of pathogens. During hybridization reactions, electrochemical DNA biosensors utilize immobilized ssDNA probe to capture a target complementary ssDNA sequence via hydrogen bond formation. However, the inability to monitor the recognition signals without resorting to the use of labels, electroactive mediators or other ligands has led to DNA devices with inadequate sensitivity. In this presentation, we will present efforts in the author's group on a new DNA sensor platform, via metal-enhanced electrochemical detection (MED) biosensors. MED concept will be presented for protein-protein, DNA-DNA and DNA-small molecule interactions.