Omar De Paolis, Mohammed Abid, and Bela Torok. University of Massachusetts Boston, Boston, MA
Indole skeleton is one of the most prevalent building units in wide range of biologically active and pharmacologically useful compounds including many natural products. Herein, we report a novel one-pot synthesis of N-acylindoles via tandem Paal-Knorr cyclization/annelation of primary aromatic amides. This new method involves the use of a solid acid catalyst and microwave irradiation under solvent-free conditions. The reaction proceeds in very short reaction times providing excellent yields and selectivities.

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