Chemists are exceptionally skilled at designing and constructing individual molecules with the goal of imbuing them with defined chemical and physical properties. However, the task of rationally assembling them into organized, functional supramolecular structures with precise, nanometer-level control is a daunting challenge. In this lecture, approaches to addressing this problem are described in which the ultimate goal is the fabrication of organic electronic circuit by printing techniques. Issues here concern not only the rational design of high-mobility p- and n-type organic semiconductors, but also dielectrics with ultra-high capacitance, low leakage, and high breakdown fields.