This presentation will discuss the design and properties of block copolymers constructed by linear and perfectly branched (dendritic) segments that can self-assemble into supramolecular structures in aqueous media.1 The proven capability to selectively bind hydrophobic substrates2 and adhere to polysaccharides3 initiated the evaluation of these micellar complexes as universal nanoreactors for environmentally benign Diels-Alder reactions and enzyme-catalyzed biotransformations of hydrophobic substances in water. References 1 I. Gitsov and J.M.J. Fréchet "Solution and Solid State Properties of Hybrid Linear-Dendritic Copolymers" Macromolecules 1993, 26(24), 6536 2 I. Gitsov, K.R. Lambrych, V.A. Remnant, R. Pracitto "Micelles with Highly Branched Nanoporous Interior. Solution Properties and Binding Capabilities of Amphiphilic Copolymers with Linear Dendritic Architecture" J. Polym. Sci., Part A: Polym. Chem. 2000, 38, 2711 3 J.M.J. Fréchet, I. Gitsov, Th. Monteil, S. Rochat, J.F. Sassi, C. Vergelati, D. Yu "Modification of Surfaces and Interfaces by Non-covalent Assembly of Hybrid Linear-Dendritic Block Copolymers: Poly(benzyl ether) Dendrons as Anchors for Poly(ethylene glycol) Chains on Cellulose or Polyester" Chem. Mater. 1999, 11, 1267