Fehmi Damkaci, Michael Bovino, Drew Camelio, and Adam Stringer. State University of New York at Oswego, Oswego, NY
The compound Pterocellin A is a natural compound that was extracted from marine life off of the coast of New Zealand in 2001. Pterocellin A shows high anti-cancer properties (for P388 cancer cells IC50 = 477 ng/mL) in-vitro studies, but not in-vivo studies. A total synthesis of Pterocellin A has previously been published using thirteen steps. Our new total synthesis includes five steps, including a decarboxylative cyclization as the key step, of which four of them have been completed successfully. The convergent strategy of the synthesis will allow for diversification in order to generate analogs of the natural product to improve its in vivo activity.