Monday, June 30, 2008 - 11:10 AM
Diamond I (Sheraton Burlington Hotel and Conference Center)
92

Novel Sensors That Selectively Detect Zn(II) Over Cd(II) and Hg(II)

Roy P. Planalp1, Daniel P. Kennedy1, Antonio G. DiPasquale2, and Arnie L Rheingold2. (1) University of New Hampshire, Durham, NH, (2) University of California - San Diego, La Jolla, CA

A set of reporters of Zn(II) have been designed, synthesized and characterized, based on ‘TAME’ (TAME = 1,1,1-tris(aminomethyl)ethane) framework with aminoisoquinoline groups. It would be expected that the TAME framework would provide a better fit to smaller metal ions, i.e. to Zn(II) vs. Cd(II). The fluorescence detection selectivity of 1 and 2 for Zn(II) vs. Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Cd(II), Na(I), K(I), Ca(II) and Ag(I) will be discussed. Photophysical studies revealed that in the presence of Zn(II) 2 emits in the UV (λex = 326nm, λem = 360nm) but possesses an enhanced quantum yield ΦZn-2 = 12.7% as compared to Zn-1. The potential biological applications of 1 and 2 will be discussed.


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