Monday, June 30, 2008: 8:30 AM-12:10 PM
Amphitheater (Sheraton Burlington Hotel and Conference Center)
Medicinal Chemistry I
Lead Generation
Case studies in hit-to-lead chemistry, analysis of triage of HTS results, Library generation for hit expansion, etc.

Lead Optimization (Sponsored by AstraZeneca)
Case studies across a variety of therapeutic areas, illustrating the successful identification and optimization of leads to generate clinical candidates.
Organizer:Scott Cowen
Part 1 
8:30 AM50Diversity Oriented Synthesis of Small Molecule Heterocyclic Compound Libraries
Brian T. Gregg, John F. Quinn, Dmytro O. Tymoshenko, Kathryn C. Golden, Dana A. Razzano
9:00 AM51Aspects of Hit to Lead
Adrian Hobson
9:30 AM248Probing the Mechanism of Scheinfurthin Action: Synthesis and Biological Action of Fluorescent Schweinfurthin Analogs
Jeffrey D. Neighbors, Craig H. Kuder, Joseph J. Topczewski, Raymond J. Hohl, David F. Wiemer
9:50 AM53The Discovery of g-Carbolines as Peripherally-Restricted CB1 Agonists for the Treatment of Pain – Hit Generation and Hit to Lead
Mirek Tomaszewski
10:10 AM Break
Part 2 
10:30 AM54Tetramic Acids and More: Discovery of Potent & Selective Leads Inhibiting Undecaprenyl Pyrophosphate Synthase (UPPS)
Stefan Peukert
11:00 AM55The Path to a Potent, Selective and Orally Bioavailable C-Met Inhibitor with Antitumor Activity
David Bauer
11:30 AM56Discovery of Potent Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine
Prasad Chaturvedula
11:50 AM57Effective Reaction Screening, Development, and Scale-up Using Statistical Design of Experiments (DoE)
Andrei A. Zlota

Back to The Northeast Regional Meeting (NERM) (June 29 - July 2, 2008)