Tuesday, July 1, 2008: 7:15 PM-9:15 PM
Emerald II (Sheraton Burlington Hotel and Conference Center)
Medicinal Chemistry II
Bench to Clinic
Talks highlighting successful preclinical projects resulting in the generation of clinical candidates.
Topics include scale-up and process chemistry, translational science, pre-clinical challenges, etc.
Organizer:Scott Cowen
7:15 PMLead Optimization and Candidate Selection of Novel Allosteric MEK Inhibitors for the Treatment of Cancer
Andreas Goutopoulos
7:45 PMThe Discovery and Early Development of ARQ 197, a Selective C-Met Inhibitor
Mark A. Ashwell
8:15 PMDesign, Synthesis and Activity of Inhibitors of Focal Adhesion Kinase: Discovery of PF-562271 Currently In Clinical Trials
Michael J. Luzzio, Christopher Autry, Martin Berliner, Kevin Coleman, Beth Cooper, Erika Desrosiers, Erling Emerson, Matt Griffor, Catherine Hulford, Jitesh P. Jani, John Kath, Susan LaGreca, Jing Lin, Marianne Lorenzen, Eric Marr, Luis Martinez-Alsina, Nandini Patel, Daniel Richter, Ethan Ung, Felix Vajdos, Mathew Wessel, Pamela Whalen, Lili Yao, W Gregory Roberts
8:45 PMPET Radiochemistry: Synthesis Using Short-Lived Isotopes
Terence G. Hamill

Back to The Northeast Regional Meeting (NERM) (June 29 - July 2, 2008)