In the past fifth teen years, surface plasmon resonance biosensors have gone from a relatively obscure technology to supporting an extremely wide range of pharmaceutical and life science applications. Label-free and real-time detection allows the technology to be used to characterize the binding of nearly any biomolecular system including: proteins, nucleic acids, lipids, oligosaccarides, and even small molecules. As the technology continues to evolve we are seeing instruments developed for more dedicated applications such as high throughput screening and quality control. This presentation will provide a tour of emerging biosensor technology and evolving applications.