Azaspiracid-1, a toxin found in edible mussels, is an attractive synthetic target due to its unique structural architecture and toxicity. Our initial retrosynthetic strategy dissected the southern FGHI ring system 2 into the two major fragments A and B. The synthesis of the two fragments and the outcome of this strategy will be presented. In addition, our progress toward the revised strategy with coupling partners C and D will also be described.