Tuesday, 17 October 2006 - 1:30 PM
Salon C (Doubletree Hotel at Reid Park)
263

Photochemical Strategies for Nitric Oxide Delivery to Biological Targets

Peter C. Ford, University of California at Santa Barbara, Santa Barbara, CA

      SEQ CHAPTER \h \r 1We have been investigating a series of metal nitrosyl (M-NO) and nitrito complexes (M-ONO) designed to release nitric oxide photochemically.1-5 The goal is to tailor such compounds for the delivery of NO to specific biological targets for potential therapeutic applications.  Strategies for such photochemical drugs based on activation by single and two-photon excitation are being pursued, and in order to obtain favourable photophysical properties, a series of supramolecular compounds have been prepared with multiple chromophores (e.g., see figures) and characterized.  In this presentation, we will present an overview of our approach and discuss the photochemistry and photophysics of several such complexes that are currently under investigation.


 

 


 

 

 

References:

1.   P. C. Ford, J. Bourassa, K. Miranda, B. Lee, I. Lorkovic, S. Boggs, S. Kudo, L. Laverman  Coord. Chem. Revs., 1998, 171, 185-202.

2.   C. L. Conrado, S. Wecksler, C. Egler, D. Magde, P. C. Ford, Inorg. Chem. 2004; 43, 5543-5549

3.   S. Wecksler, A. Mikhailovsky, P. C. Ford, J. Amer. Chem. Soc. 2004; 126, 13566-13567.

4.   F. DeRosa, X. Bu, P. C. Ford,  Inorg. Chem., 2005, 44,  4157-4165

5.   E. S. Baker et al, J. Amer. Chem. Soc. 2005, 127, 18222-18228

6.   S. R. Wecksler et al, Inorg. Chem. 2006,  45,  1192-1200

7.   S. R. Wecksler, A. Mikhailovsky, D. Korystov, P.C. Ford. J. Amer. Chem. Soc. 2006 in press


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