The syntheses of two inhibitors of sphingolipid metabolism, fumonisin B₁ and D-threo-PDMP, have been performed. These two compounds commonly have D- or L- threo amino alcohol functionality, which may be obtained by stereoselective reductive alkylation of the fully protected O'Donnell's Schiff base as a key step. Other synthetic methodologies to yield these molecules will also be introduced. While D-threo-PDMP (1R, 2R-1-phenyl-2-decanoylamino-3-morpholino-1-propanol) is known to be the inhibitor of glucosylceramide, the fumonisin B₁ has been investigated due to its inhibitory function against the generation of ceramide in de novo biosynthesis.