Many variables affect solid-state NMR spectral acquisition, including relative peak intensities and line widths. The homogeneity of the magnetic field within the bore of the magnet is one variable that should be held constant. It was the purpose of the research to: 1. Observe the relative effect that an inhomogeneous magnetic field has on four different analytically significant samples: Adamantane, HMB, Ibuprofen, and 3-Methyl Glutaric Acid (MGA). 2. To determine the effect of probe movement on the magnetic field observed by the sample.

The observed line widths of adamantane, HMB, Ibuprofen, and MGA all increased (but to various extents) when moved outside of the homogeneous region of the magnet. Adamantane showed the largest increases in line width as a function of distance from the homogeneous region. Movement of the single-sample probe produced eddy currents, which distorted the homogeneity of the magnetic field. Adamantane spectra showed that this distortion remained for approximately 15 seconds.

Adamantane line widths were very sensitive to changes in magnetic field homogeneity. However, HMB, Ibuprofen, and MGA line widths did not change dramatically. This suggests that field homogeneity is not as detrimental toward spectral acquisition as previously thought. Additionally, it was found that the effects of field inhomogeneity can be minimized by packing samples within a small vertical space of the sample rotor. In the single-sample probe, movement of the probe caused a disruption of magnetic homogeneity for at least 15 seconds. Thus, in multiple-sample probe design, eddy currents could be a concern in homogeneous spectral acquisition.