Thursday, October 25, 2007
Ballroom Posters (Greenville Hyatt Regency Hotel)
119

A combination strategy for the preparation of rigidins b, c and d

John T. Gupton, Lizzie Rieck, Kristin Smith, and Anastasia Kharlamova. University of Richmond, Richmond, VA

Our research group has been interested in the synthesis of pyrrole containing marine natural products by utilization of vinylogous iminium salt precursors. Our previous strategy allowed for the successful synthesis of rigidin and rigidin E, which are pyrrolopyrimidine alkaloids. We anticipate that this same strategy can be utilized for the synthesis of the remaining members of this family of pyrrole containing alkaloids. Ongoing work in this area will be presented.