Prior to the widespread use of Statin drugs to lower serum cholesterol levels, it was reported that ingestion of activated carbon powder could significantly lower total cholesterol levels in both animal and human subjects. Activated carbon routinely has been used to treat drug overdose victims. As activated carbon powder passes through the gastrointestinal system, it can remove molecules that adhere to the carbon surface by physical adsorption. Cholesterol is a hydrophobic molecule that is held in bile salt based micelles in the small intestines during the digestion process and should be strongly adsorbed on a nonpolar carbon surface. Solution phase adsorption experiments were used to assess the ability of various carbon powders to take up and hold cholesterol molecules through physical adsorption. Comparisons of cholesterol-surface binding energies and adsorption capacities per gram of carbon were made for various carbon powders having a range of surface areas and pore structures. The daily amount of dietary ingested and bodily produced cholesterol is approximately 1 to 2 grams. Our results suggest a relatively small amount of suitable carbon (10 to 20 grams) could potentially hold 1 to 2 grams of cholesterol.