Hydrogen fuel provides an environmentally friendly energy source and further eliminates the dependency of natural resources. Several challenges exist that limit the efficiency of hydrogen production including the solar-driven water splitting processes. An alternative and new approach is to rationally organize nanoscale materials to store multiple redox equivalents. Surface functionalization of semiconductor nanoparticles with appropriate catalytic nanoparticles and/or molecular catalysts provides a versatile tool for the development of multi-electron catalysts. These systems are capable of driving energetically demanding transformations and their investigation has allowed for the underlying mechanistic principles to be understood. These redox equivalents have been found to react rapidly with H₂O molecules generating H₂ gas. Variations in the ratio of the concentrations of semiconductor to concentration of catalysts were investigated. The presentation will focus on catalyst design, assembly and optimization of catalysts for the generation of hydrogen from water.