The antibiotic cytosporone E, isolated in 2000 and found to have weak antibiotic activity, has recently been found to only display activity against gram-positive bacteria. The apparent "business end" of the molecule contains three phenolic moieties, of which the central moiety is need for antibiotic activity. What is the role of this central hydroxy group? Does it necessarily have a specific function, or does the molecule simply need something in this position to take up space? To help determine its role a derivative will synthesized, where a vinyl group will take the place of the central hydroxy group. This vinyl group will be replaced with different substituents with varying properties that will help in the development of a structure activity relationship (SAR) study to hopefully improve the antibiosis of the antibiotic.