Ethanolic extracts of eleven widely used medicinal plants which are thought to have cyclooxygenase-2 (COX-2) inhibitory effects and/or have been implicated as endocrine disruptors were tested on the H295R adrenal cortical tumor cell line for cytotoxic effects. Cytotoxicity was evaluated by a cell viability assay using MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) or MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). Of the 11 ethanolic extracts tested only three; Sanguinaria candensis (Blood root), Zingiber officinali (Ginger root), and Serenoa repens (Saw Palmetto), were shown to have cytotoxic effects on the H295R cell line. These three plant extracts were further tested for their ability to induce apoptosis in H295R cells. Of the three, only Ginger root appears to stimulate the Caspase 3/7 apoptotic pathway. Since the H295R cell line has been used to study adrenocortical tumorigenesis mechanisms, the anti-proliferative and apoptotic effect of Ginger root suggests that it may be a viable treatment for adrenal cancer.