Friday, October 20, 2006
Ground Foyer ( Houston Westchase Marriott Hotel)
321

Interactions of Carbon Nanotubes with a Histidine Containing Designed Peptide

Virginia Isabel Buhl and Gregg R. Dieckmann. University of Texas at Dallas, Richardson, TX

This project seeks to functionalize carbon nanotubes (CNTs) through the use of designed peptides. We have developed a series of amphiphilic alpha helical peptides which are able to bind to CNTs, effectively dispersing them in solution. In this project, we will compare the binding affinities of two of these peptides; nano-1 (containing Val in a positions and Phe at d positions of a heptad repeat) versus (HaFd)4 (a derivative of Nano-1 with His located in the a position and Phe in the d position). Preliminary results of CD spectroscopy of (HaFd)4 alone show molar ellipticity increases with increased peptide concentration. An increase in molar ellipticity was also observed to be linked to decreases of pH in solution, although further experimentation must be done in order to verify these results. The ability of the peptides to disperse CNTs in solution, as well as the CD of the resulting peptide/CNT dispersions, will also be determined and discussed.