379 Synthesis and Biochemistry of Bacterial Furanosides

Friday, November 6, 2009: 11:00 AM
Angus (Camino Real Hotel)
Todd L. Lowary , Department of Chemistry, The University of Alberta, Edmonton, AB, Canada
A number of pathogenic bacteria, fungi and parasites produce glycoconjugates containing furanose rings.  These species are often essential to the life cycle of these organisms and hence the biochemical pathways that assemble them are potential sites for the action of novel anti-infective agents.  Presented in this seminar will be recent work from our group on the synthesis and subsequent biochemical investigations of glycoconjugates containing furanose rings. Particular emphasis will be placed on studies of a galactofuranosyltransferase involved in the assembly of the cell wall in the organism that causes tuberculosis (Mycobacterium tuberculosis) and pyranose–furanose mutases from Campylobacter jejuni, an important food-borne pathogen.