Wednesday, November 4, 2009: 10:20 AM
Rio Grande (Camino Real Hotel)
Within the framework of our systematic studies of biologically active fused heterocycles, 2-alkyl, 2-aryl, and 2-halo (Cl, Br) substituted 5H-6-fluoro-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-ones have been synthesized and their conversions into other derivatives have been investigated. 2-Substituted 5-amino-1,3,4-thiadiazoles were used as the starting materials and were reacted with ethyl 2-fluoroacetoacetate in polyphosphoric acid. Also, 5H-2-fluoro-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-ones with the hydrazine moiety in the position 2 were prepared. The new compounds are expected to be biologically active.
Acknowledgement. The award of a Fulbright Scholar grant (administered by the Council for International Exchange of Scholars) to M. A. Kukaniev is gratefully acknowledged.