117 Synthesis and Conversions of Substituted 6-Fluoro-1,3,4-Thiadiazolo[3,2-a]Pyrimidines

Wednesday, November 4, 2009: 10:20 AM
Rio Grande (Camino Real Hotel)
Cyril Párkányi , Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL
Mukhamadsho A. Kukaniev , Laboratory for Heterocyclic Compounds, V. I. Nikitin Institute of Chemistry, Academy of Sciences of the Republic of Tajikistan, Dushanbe, Tajikistan
Within the framework of our systematic studies of biologically active fused heterocycles, 2-alkyl, 2-aryl, and 2-halo (Cl, Br) substituted 5H-6-fluoro-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-ones have been synthesized and their conversions into other derivatives have been investigated.  2-Substituted 5-amino-1,3,4-thiadiazoles were used as the starting materials and were reacted with ethyl 2-fluoroacetoacetate in polyphosphoric acid.  Also, 5H-2-fluoro-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-ones with the hydrazine moiety in the position 2 were prepared.  The new compounds are expected to be biologically active.

Acknowledgement. The award of a Fulbright Scholar grant (administered by the Council for International Exchange of Scholars) to M. A. Kukaniev is gratefully acknowledged.

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