Abstract: Diarylprolinol Silyl Ether, A Highly Effective Chiral Organocatalyst for the Asymmetric Michael Addition in Water (65th Southwest Regional Meeting)

Wednesday, November 4, 2009

Ballroom A+B (Camino Real Hotel)

Subrata Ghosh , Department of Chemistry, Texas A&M University - commerce, Commerce, TX

Zilong Zheng , Department of Chemistry, Texas A&M University - commerce, Commerce, TX

Allan D Headley , Department of Chemistry, Texas A&M University - commerce, Commerce, TX

Bukuo Ni , Department of Chemistry, Texas A&M University - commerce, Commerce, TX

A highly effective water-soluble chiral organocatalyst, diaryl prolinol silyl ether, have been developed and prepared for the asymmetric Michael addition reaction of nitroalkanes and various α,β unsaturated aldehydes in water affording the Michael products with high yield and enantioselectivity. This process provides synthetically useful and highly functionalized organic compounds which can easily lead to more complexes moleculars. In addition, the simple operational procedure and the use of green solvent made this highly attractive.

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54 Diarylprolinol Silyl Ether, A Highly Effective Chiral Organocatalyst for the Asymmetric Michael Addition in Water