Wednesday, November 4, 2009
Ballroom A+B (Camino Real Hotel)
A highly effective water-soluble chiral organocatalyst, diaryl prolinol silyl ether, have been developed and prepared for the asymmetric Michael addition reaction of nitroalkanes and various α,β unsaturated aldehydes in water affording the Michael products with high yield and enantioselectivity. This process provides synthetically useful and highly functionalized organic compounds which can easily lead to more complexes moleculars. In addition, the simple operational procedure and the use of green solvent made this highly attractive.