315 Mobility Based Gas-Phase Ion Filters Between Ambient Ionization Sources and a Mass Spectrometer

Thursday, November 5, 2009: 12:50 PM
Angus (Camino Real Hotel)
Fatkhulla K. Tadjimukhamedov, Ph.D. , Chemistry, Purdue University, West Lafayette, IN
Benefits of gas-phase ion mobility based ion filter devices have been acknowledged during the past decade when various types of such devices were coupled to mass spectrometers in attempts to solve the hard to interpret mass spectra with complex multiple charge distributions or to simplify the ion population generated by ambient ionization sources, such as electrospray ionization. Among these devices, traditional Drift-Time Ion Mobility Spectrometry (IMS) and Differential Mobility Spectrometry (DMS), also known as High-Field Asymmetric Ion Mobility Spectrometry (FAIMS), have been successfully implemented to aid mass spectrometry in unscrambling the challenges faced in biochemistry, medicine, and biology. This presentation addresses the developments achieved in the fields of IMS and DMS in Gary Eiceman’s research team at NMSU, one of the pioneers in development of micromachined DMS instruments. A translation of this technology to miniature mass spectrometry and improvements that it offers to the performance of miniature mass analyzers with limited performance will also be presented. Moreover, novel low mobility pass filters (LMPF), developed in the Eiceman research group, and their potential to simplify the ion population before mass spectrometry will be discussed.