74 Effect of Secondary Bonding in Tetravalent Tin Geometry and Biological Activity: (2-MeE-Bz)2SnCl2, E= O and S, and [Mes(CH2)3]2SnCl2

Wednesday, November 4, 2009: 11:30 AM
Angus (Camino Real Hotel)
Alejandro J. Metta-Magana , Department of Chemistry, University of Texas at El Paso, El Paso, TX
Francisco Cervantes-Lee , Department of Chemistry, University of Texas at El Paso, El Paso, TX
Keith H. Pannell , Department of Chemistry, University of Texas at El Paso, El Paso, TX
Diana G. Vargas-Pineda , Department of Chemistry, University of Texas at El Paso, El Paso, TX
Margaret Whalen , Department of Chemistry, Tennessee State University, Nashville, TN
The tetravalent tin has the ability to be coordinated by Lewis bases as N, O, and S, via both intra and inter-molecular interactions changing its geometry from tetrahedral to tetrahedral monocapped, trigonal bipyramidal, tetrahedral bicapped, and octahedral.  Is known that the biological activity of the organotins is related to their geometry so in this work we explore how the nature of the donator atom affects the geometry observed in the crystal structure for a specific system: (2-MeE-Bz)2SnCl2 where E = O and S; and we also compared the o-methoxy compound  with the meta- and para-isomers.  And the architecture of the crystal is analyzed. Another interesting example is [MeS(CH2)3]2SnCl2 where the solid state hexacoordinated geometry at tin, which is retained in solution, dramatically alters the capacity of the organotin to impact the human natural killer cell activity.