Seeking Novel Reactivity and Selectivity in Modern Organic Synthesis

Achieving high chemoselectivity in functionally complex systems under mild reaction conditions is a significant 21^st century challenge for synthetic scientists.  In contrast to biological processes, where exquisite selectivity is achieved in vivo in functionally very complex systems through the fine-tuning of protein structure to function, achieving high chemoselectivity on functionally complex molecules in non-enzymatic systems in vitro requires alternative strategies of control.  This lecture will describe new strategies for highly selective bond constructions that employ new and useful reactivity principles.