Wednesday, November 4, 2009
Ballroom A+B (Camino Real Hotel)
Neem (Azadirachta indica) and Neem leaf extracts have been used as a traditional remedy in India for a variety of illnesses. Recent and preliminary data from our labs has demonstrated that Neem leaf extract induces necrosis and apoptosis in mouse models of breast cancer. Furthermore, an additional observed benefit is that the Neem leaf extract reduces side-effects associated with traditional chemotherapy/radiation. We hypothesize that certain principals in the Neem leaf extract scavenge free radicals, thereby mitigating cancer pathogenesis. In our study, model free radical reactions are used to mimic cellular reactive oxygen species and assess the scavenging potential of select Neem constituents. HPLC and Mass Spectrometry are then used to determine the identity of these principals. Future work include translation of identified active Neem principals in cell lines and/or mouse models that will help us pinpoint bioactive ingredients found in Neem leaf extract that are responsible for the mitigation of cancer pathogenesis.