25 Targeting Nitrosative Stress Effects On An ER-Resident Oxidoreductase through Small-Molecule Ethnopharmaceutical Intervention: Implications for Age - and Neurodegeneration-Related Disorders

Wednesday, November 4, 2009
Ballroom A+B (Camino Real Hotel)
Karina Schnittker, Undergraduate Student , Department of Biological Sciences, University of Texas at El Paso, El Paso, TX
Rituraj Pal, Graduate Student , Department of Chemistry, University of Texas at El Paso, El Paso, TX
Mahesh Narayan , Department of Chemistry, University of Texas, El Paso, El Paso, TX
Misfolded proteins, and the associated endoplasmic reticulum (ER) stress, are emerging as hallmarks of age- and neurodegeneration-related disorders such as Huntington’s disease (HD), Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis. Recent and compelling evidence has linked nitrosative stress and the ER-resident oxidoreductase, protein disulfide isomerase (PDI), to the pathogenesis of PD and AD. Overexpression of PDI has been found to reduce the formation of polyubiquitinated proteins, making the oxidoreductase an important target for therapeutic intervention in PD, AD and other age- and neurodegeneration-related disorders. We demonstrate the NO-scavenging ability of the biphenolic natural products curcumin and masoprocol and the concomitant prevention of S-nitrosylation of PDI by a model NO-donor. Furthermore, both ethnopharmaceuticals accelerate protein fold acquisition in their neat and nitrated forms, making them attractive candidates for prevention of age- and neurodegeneration-related diseases.
See more of: Wednesday Poster Session
See more of: Abstract Submission