433 Polyurethane-Chitosan Composites for Biomedical Aplications

Friday, November 6, 2009: 9:40 AM
Pancho Villa (Camino Real Hotel)
Imelda Olivas , Basic Science, Institute of Engineering and Tecnology, Autonomus University of Juarez City, Juarez, Mexico
Perla Garcia Casillas , Basic Science, Institute of Engineering and Tecnology, Autonomus University of Juarez City, Juarez, Mexico
Alberto Villafaņe , Physics, Materials Research Center, Chihuahua, Mexico
Laura De la Rosa , Basic Sciences department, Institute of Biomedical Science, Autonomus University of Juarez City, Juarez, Mexico
Carlos A. Martinez , Basic Science, Institute of Engineering and Tecnology, Autonomus University of Juarez City, Juarez, Mexico
The synthesis and characterization of polyurethane (PU)-chitosan(CH) porous composites prepared by thermal induced phase separation (TIPS) and its possible application for tissue engineering are described. This processing method has been tuned to allow intimate (molecular) mixing of these two different polymers, giving rise to a unique morphology that can be manipulated by controlling the phase separation behavior of an initially homogenous polymer solution. The thermal stability was characterized by thermo gravimetric analysis (TGA) and differential scanning calorimetry (DSC), evidence of the interaction between both polymers was acquired from infrared spectroscopy (IR) and DSC. Morphology characterization of the scaffolds was studied by scanning electron microscopy also the mechanical properties were acquired. The composites were tested into a simulated body fluid (SBF) with similar ionic composition of the blood plasma for different period of time where a bonelike apatite layer was formed as indicative of the bioactivity of the composites. The obtained results showed that the TIPS is an appropriate technique for the production of PU-CH porous composites that could be applied for biomedical applications.