284 Reactions of Early Transition Metal Complexes with Carbon Dioxide

Thursday, November 5, 2009: 12:00 PM
Longhorn (Camino Real Hotel)
Shizue Mito , Department of Chemistry, The University of Texas at El Paso, El Paso, TX
Zachary Martinez , Department of Chemistry, The University of Texas at El Paso, El Paso, TX
Daniel Castillo , Department of Chemistry, The University of Texas at El Paso, El Paso, TX
Carbon dioxide is an attractive C-1 building block in organic synthesis because it is abundant, nontoxic and non-flammable. Although the fixation of carbon dioxide promoted by organometallic complexes has experienced significant progress in recent times, it still represents a growing and promising area of research.
Meanwhile, the synthesis of novel non-proteinogenic alpha-amino acids remains a subject of considerable interest because their great importance in biology, medicine, and synthetic chemistry. In particular, the variety of non-proteinogenic amino acids have played a special role in the design of peptides with enhanced properties in three-dimensional structures.
 We are seeking a new synthetic method of amino acids with carbon dioxide using transition metals. The method involves oxidative coupling of an imine and carbon dioxide with an early transition metal complex. The key of this research is regioselective oxametallacycle formation and  the reaction scope and limitation will be discussed.