The aim of this research is to prepare chiral 2- oxzaolinyloxy -substituted carbanions, and study their enantioselective reaction with aldehydes. It is hypothesized that the anion will be formed by direct deprotonation of a chiral compound and will do so at a high degree of enantioselectivity. In obtaining such results, the carbanions will then react with achiral electrophiles such as aldehydes to produce a chiral alcohol. This protocol can provide an easy access to optically active alcohols in the middle of a long chain that are otherwise inaccessible.
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Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)