Tuesday, 24 May 2005 - 1:30 PM
597

This presentation is part of: College Student Award Symposium sponsored by the Chromatography Forum of Delaware Valley

Headspace SDME Using a Single Solvent: An Application to Residual Solvents Analysis

Derrick C. Wood and James M. Miller. Drew University, Madison, NJ

One of the newer sampling techniques, similar to SPME, is sometimes called SDME or single-drop microextraction. In its simplest form, a microliter of extracting solvent is suspended from a conventional microsyringe in the headspace of a heated sample. After a few minutes, the drop is withdrawn into the syringe and injected to a GC for analysis. In this research, headspace SDME was applied to residual solvents analysis and was found to be reliable, simple, and inexpensive.

Numerous aspects of headspace SDME were examined, including the use of N-methylpyrrolidone (NMP) as both the extraction solvent and raffinate, and a comparison of manual and automated techniques. Manual injections using an internal standard had an RSD of 2.7%, and automated injections showed similar results (2-4%) even without an internal standard. Limits of detection were in the sub-ppm level.



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