Monday, 23 May 2005
315

This presentation is part of: Bench Top to Pilot Plant Posters

Nucleophilic displacement at suitably activated secondary benzylic alcohol by a sulfonamide-Development and scale-up for the preparation of an intermediate in the synthesis of a drug candidate in Alzheimer's disease

Ming Yang, M. Saindane, C. Nilsen, A. Staab, K. Gesenberg, K. Wong, T. Vu, Z. Shi, J. Fan, G. Crispino, Y. Pendri, Siva J. Prasad, and A. Singh. Bristol-Myers Squibb Company, New Brunswick, NJ

The compound under investigation is an intermediate for an Alzheimer disease drug candidate. This poster presents the synthetic evolution from discovery chemistry to chemistry sucessfully scaled up in the pilot plant. The scale up issues and remedies are also addressed.

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Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)