Tuesday, 24 May 2005

This presentation is part of: Organic Posters

A Practical One-Pot Preparation of 7-Hydroxyquinoline

R. Scott Hoerrner, Mark Cameron, Shawn Springfield, James McNamara, and Ulf Dolling. Merck & Co., Rahway, NJ

An efficient, practical, one-pot preparation of 7-hydroxyquinoline, a key intermediate in a series of pharmaceutical drug candidates, is described. The procedure addresses safety concerns in handling highly toxic acrolein, as well as providing a high-yielding and direct isolation of crystalline 7-hydroxyquinoline from the crude reaction mixture.

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