Monday, 23 May 2005
316

This presentation is part of: Bench Top to Pilot Plant Posters

Process Development for Pilot Plant Synthesis of Methyl 2-Bromo-6-chlorobenzoate

Matthew R. Hickey, Shawn P. Allwein, Todd D. Nelson, Michael H. Kress, Osama S. Sudah, Mahmoud Kaba, Aaron J. Moment, and Paul Fernandez. Merck Research Laboratories, Wayne, PA

Development of a scalable process for the synthesis of methyl 2-bromo-6-chlorobenzoate is described. Focus will be on the development of the process from screening of various routes to route selection and implementation on 50+ kg scale in a pilot plant. A critical cryogenic temperature requirement is essential to avoid exothermic decomposition via a benzyne type pathway. Other features of this route include an acid/base extractive workup, a single purification by crystallization, inexpensive and readily available starting materials, and scale independent isolated yields around 80% over both steps.


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