Tuesday, 24 May 2005
717

This presentation is part of: Organic Posters

Reactivity Of Tris(Trimethylsilyl)Phosphite (TMSP): Attempt to prepare the N-mustard-bis Phosphonic acid of Bicine

Ji Suh, Queensborough Community College, St.John's University, Bayside, NY, Luis Vargas, Queensborough Community College, Bayside, NY, and Ralph Stephani, St. John's University, Jamaica, NY.

Steps in the conversion of bicine (bis-N,N-dihydroxyethyl- glycine) into the N-mustard-bis-phosphonic acid, using TMSP, are described. The object is to combine the alkylating action of the nitrogen-mustard group with the directing properties of the bis-phosphonic acid to develop a more efficient drug against bone cancer.

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