Tuesday, 24 May 2005

This presentation is part of: ADMET Posters

Distribution of Periodontopathic Bacteria Among Asian Indians

Shari Smith, Elizabeth Pelaez, Raji Subramaniam, and Patricia Schneider. Queensborough Community College, Bayside, NY

Anaerobic gram-negative bacteria, in particular Prophyromonas gingivalis, Treponema denticola, and Tanneiella forsythensis, are associated with severe forms of adult periodontal disease. Demographic characteristics, such as age, gender and race, have been shown to influence both the incidence of periodontal disease and the bacterial composition of subgingival plaque. However, the impact of these factors on Asian populations is largely unknown. This study investigated the prevalence of the three pathogens in Asian Indian periodontal patients at a private dental clinic. Periodontal bacteria were detected by enzyme assay ( BANA hydrolysis) and PCR using specific 16s rRNA probes. We examined the relationship between bacterial distribution, BANA score, demographic factors (age and gender) and clinical parameters (pocket depth, dental history and bleeding on probing). Strong positive correlations were found between the severity of Periodontitis (pocket depth), BANA intensity and patient age. All three anaerobic pathogens were detected with equal frequency, but mixed infections were only found in patients with moderate to severe Periodontitis. These results indicate that all three bacteria are significant pathogens in the Asian Indian Population, however disease progression appears to be associated with mixed infection. Shari Smith and Elizabeth Pelaez are participants in the NIH Bridges to the Baccalaureate Program at Queensborough Community College (grant 1 R25 GM65096-03).

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