Tuesday, 24 May 2005

This presentation is part of: Organic Posters

Synthesis of a Merck NK-1 receptor antagonist

Jason J. Kowal, Merck & Co., Rahway, NJ

Substance P (NK-1) receptor antagonists have been shown to be potential therapeutic agents for a wide variety of important medical disorders. Among these, substance P has been shown to be effective in the treatment of chemotherapy-induced nausea and vomiting which led Merck to the identification of Aprepitant. Herein, we describe the synthesis of another Merck NK-1 receptor antagonist.

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