Tuesday, 24 May 2005 - 10:30 AM

This presentation is part of: Stars, Branched, Graft and Dendritic Polymers

Dendrimers for Dual Imaging Modalities: Combining Magnetic Resonance and Optical Fluorescent Imaging

Vladimir S. Talanov1, Hisataka Kobayashi1, Marcelino Bernardo1, Moinuddin Hassan2, Amir H. Gandjbakhche2, Peter L. Choyke1, and Martin W. Brechbiel1. (1) National Cancer Institute, NIH, Bethesda, MD, (2) National Institute of Child Health and Human Development, NIH, Bethesda, MD

The advantages of using dendrimeric chelated Gd-containing contrasting agents to enhance magnetic resonance imaging (MRI) by increasing molar relaxivity have already been well documented. We now describe dendrimeric materials conjugated with chelated Gd(III) and also with fluorescent labels for dual imaging modalities, i.e., MRI and optical fluorescent imaging.

PAMAM dendrimers were first modified with the bifunctional 1B4M-DTPA chelate. Thereafter, Gd(III) was introduced and that intermediate product was labeled with near-infrared (NIR) fluorescent cyanine dye Cy5.5 via covalent attachment to primary amines of the dendrimer. Optical studies and preliminary evaluation of the materials in vivo will be presented.

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