Tuesday, 24 May 2005 - 1:35 PM
633

This presentation is part of: Proteinase

A Novel Class of Non-Covalent Cathepsins Inhibitors

Tae-Seong Kim, Amgen Inc., Thousand Oaks, CA

A series of (4-piperidinylphenyl)aminoethyl amides based on dipeptide anilines were synthesized and tested against cathepsin K, cathepsin L and cathepsin B. These new non-covalent inhibitors exhibited single digit nM inhibition of the cysteine proteases. The potency of these inhibitors in both mouse and human osteoclast resorption assays was demonstrated.

Key words: Non-covalent, Cathepsin, Inhibitor


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