Tuesday, 24 May 2005 - 1:35 PM

This presentation is part of: Proteinase

A Novel Class of Non-Covalent Cathepsins Inhibitors

Tae-Seong Kim, Amgen Inc., Thousand Oaks, CA

A series of (4-piperidinylphenyl)aminoethyl amides based on dipeptide anilines were synthesized and tested against cathepsin K, cathepsin L and cathepsin B. These new non-covalent inhibitors exhibited single digit nM inhibition of the cysteine proteases. The potency of these inhibitors in both mouse and human osteoclast resorption assays was demonstrated.

Key words: Non-covalent, Cathepsin, Inhibitor

Back to Proteinase
Back to The 37th Middle Atlantic Regional Meeting (May 22-25, 2005)