Tuesday, 24 May 2005
719

This presentation is part of: Organic Posters

S-Benzyl thioglycosidic mycothiol analogue

Michael Smerina and Spencer Knapp. Rutgers University, Piscataway, NJ

Most actinomycetes, including Mycobacterium tuberculosis, biosynthesize and maintain high levels of mycothiol (1) as protection against oxidative stress and electrophilic agents. Analogues such as (2) and (3), whose synthesis we describe, can be expected to participate in some of the same enzymatic pathways, and thus might serve as starting points for drug design.


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