Monday, 23 May 2005 - 2:50 PM
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This presentation is part of: Carbohydrates

2'-Deoxynucleosides through 2'-thio-S-acetyl participation

Srihari Pabbaraja and Spencer Knapp. Rutgers University, Piscataway, NJ

The synthesis of 2'-deoxynucleosides has been simplified through the use of the 2'-thio-S-acetyl participating group to direct N-glycosylation. Donor (1) reacts under Vorbruggen conditions to give a nucleoside that is desulfurized with Ra-Ni to give, for example, 2'-deoxyribavirin (2).


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